Elemental abundances of low-mass stars in nearby young associations: AB Doradus, Carina Near, and Ursa Major

We present stellar parameters and abundances of 11 elements (Li, Na, Mg, Al, Si, Ca, Ti, Cr, Fe, Ni, and Zn) of 13 F6-K2 main-sequence stars in the young groups AB Doradus, Carina Near, and Ursa Major. The exoplanet-host star \iota Horologii is also analysed. The three young associations have lithium abundance consistent with their age. All other elements show solar abundances. The three groups are characterised by a small scatter in all abundances, with mean [Fe/H] values of 0.10 (\sigma=0.03), 0.08 (\sigma=0.05), and 0.01 (\sigma=0.03) dex for AB Doradus, Carina Near, and Ursa Major, respectively. The distribution of elemental abundances appears congruent with the chemical pattern of the Galactic thin disc in the solar vicinity, as found for other young groups. This means that the metallicity distribution of nearby young stars, targets of direct-imaging planet-search surveys, is different from that of old, field solar-type stars, i.e. the typical targets of radial velocity surveys. The young planet-host star \iota Horologii shows a lithium abundance lower than that found for the young association members. It is found to have a slightly super-solar iron abundance ([Fe/H]=0.16+-0.09), while all [X/Fe] ratios are similar to the solar values. Its elemental abundances are close to those of the Hyades cluster derived from the literature, which seems to reinforce the idea of a possible common origin with the primordial cluster.Comment: 16 pages, 2 figures, 6 tables. Accepted for publication in MNRA

On the accretion properties of young stellar objects in the L1615/L1616 cometary cloud

We present the results of FLAMES/UVES and FLAMES/GIRAFFE spectroscopic observations of 23 low-mass stars in the L1615/L1616 cometary cloud, complemented with FORS2 and VIMOS spectroscopy of 31 additional stars in the same cloud. L1615/L1616 is a cometary cloud where the star formation was triggered by the impact of the massive stars in the Orion OB association. From the measurements of the lithium abundance and radial velocity, we confirm the membership of our sample to the cloud. We use the equivalent widths of the H$\alpha$, H$\beta$, and the HeI $\lambda$5876, $\lambda$6678, $\lambda$7065 \AA$$emission lines to calculate the accretion luminosities, $L_{\rm acc}$, and the mass accretion rates, $\dot M_{\rm acc}$. We find in L1615/L1616 a fraction of accreting objects ($\sim 30\%$), which is consistent with the typical fraction of accretors in T associations of similar age ($\sim 3$ Myr). The mass accretion rate for these stars shows a trend with the mass of the central object similar to that found for other star-forming regions, with a spread at a given mass which depends on the evolutionary model used to derive the stellar mass. Moreover, the behavior of the $2MASS/WISE$ colors with $\dot M_{\rm acc}$ indicates that strong accretors with $\log \dot M_{\rm acc} \gt -8.5$ dex show large excesses in the $JHK{\rm s}$ bands, as in previous studies. We also conclude that the accretion properties of the L1615/L1616 members are similar to those of young stellar objects in T associations, like Lupus.Comment: Accepted by Astronomy and Astrophysics. 17 pages, 11 figures, 6 table

X-shooter spectroscopy of young stellar objects in Lupus: Lithium, iron, and barium elemental abundances

With the purpose of performing a homogeneous determination of elemental abundances for members of the Lupus T association, we analyzed three chemical elements: lithium, iron, and barium. The aims were: to derive the Li abundance for ~90% of known class II stars in the Lupus I, II, III, IV clouds; to perform chemical tagging of a region where few Fe abundance measurements have been obtained in the past, and no determination of the Ba content has been done up to now. We also investigated possible Ba enhancement, as this element has become increasingly interesting in the last years following the evidence of Ba over-abundance in young clusters, the origin of which is still unknown. Using X-shooter@VLT, we analyzed the spectra of 89 cluster members, both class II and III stars. We measured the strength of the Li line and derived the abundance of this element through equivalent width measurements and curves of growth. For six class II stars we also measured the Fe and Ba abundances using the spectral synthesis and the code MOOG. The veiling contribution was taken into account for all three elements. We find a dispersion in the strength of the Li line at low Teff and identify three targets with severe Li depletion. The nuclear age inferred for these highly Li-depleted stars is around 15 Myr, which exceeds the isochronal one. As in other star-forming regions, no metal-rich members are found in Lupus, giving support to a recent hypothesis that the Fe abundance distribution of most of the nearby young regions could be the result of a common and widespread star formation episode involving the Galactic thin disk. We find that Ba is over-abundant by ~0.7 dex with respect to the Sun. Since current theoretical models cannot reproduce this Ba abundance pattern, we investigated whether this unusually large Ba content might be related to effects due to stellar parameters, stellar activity, and accretion.Comment: 15 pages, 14 figures, 3 tables; accepted for publication in A&A; abstract shortene

Haplotypes of the genes (GCK and G6PC2) underlying the glucose/glucose-6-phosphate cycle are associated with pancreatic beta cell glucose sensitivity in patients with newly diagnosed type 2 diabetes from the VNDS study (VNDS 11)

Background: Elevated fasting plasma glucose has been associated with increased risk for development of type 2 diabetes (T2D). The balance between glucokinase (GCK) and glucose-6-phosphate catalytic subunit 2 (G6PC2) activity are involved in glucose homeostasis through glycolytic flux, and subsequent insulin secretion. Aim: In this study, we evaluated the association between the genetic variability of G6PC2 and GCK genes and T2D-related quantitative traits. Methods: In 794 drug-naïve, GADA-negative, newly diagnosed T2D patients (VNDS; NTC01526720) we performed: genotyping of 6 independent tag-SNPs within GCK gene and 5 tag-SNPs within G6PC2 gene; euglycaemic insulin clamp to assess insulin sensitivity; OGTT to estimate beta-cell function (derivative and proportional control; DC, PC) by mathematical modeling. Genetic association analysis has been conducted using Plink software. Results: Two SNPs within GCK gene (rs882019 and rs1303722) were associated to DC in opposite way (both p < 0.004). Two G6PC2 variants (rs13387347 and rs560887) were associated to both parameters of insulin secretion (DC and PC) and to fasting C-peptide levels (all p < 0.038). Moreover, subjects carrying the A allele of rs560887 showed higher values of 2h-plasma glucose (2hPG) (p = 0.033). Haplotype analysis revealed that GCK (AACAAA) haplotype was associated to decreased fasting C-peptide levels, whereas, the most frequent haplotype of G6PC2 (GGAAG) was associated with higher fasting C-peptide levels (p = 0.001), higher PC (β = 6.87, p = 0.022) and the lower 2hPG (p = 0.012). Conclusion: Our findings confirmed the role of GCK and G6PC2 in regulating the pulsatility in insulin secretion thereby influencing insulin-signaling and leading to a gradual modulation in glucose levels in Italian patients with newly diagnosed T2D

Early marker of ocular neurodegeneration in children and adolescents with type 1 diabetes: the contributing role of polymorphisms in mir146a and mir128a genes

Background: Early ocular neurodegenerative signs of diabetic neuropathy (DN) can be found in children and adolescents with type 1 diabetes (T1D). No data are available on the potential role of polymorphisms in miRNAs genes in predisposing T1D subjects to these signs. Aims: To determine whether MIR146A rs2910164 and MIR128A rs11888095 polymorphisms are associated with early retinal and corneal neurodegenerative changes in pediatric patients with T1D. Methods: A total of 140 T1D children/adolescents underwent spectral domain-optical coherence tomography (SD-OCT) and in vivo confocal microscopy (IVCM) with measurement of retinal and corneal nerve fiber parameters. Risk factors for diabetes complications (diabetes duration, blood pressure, HbA1c) were recorded. Genotyping of rs2910164 and rs1188095 SNPs and genotype-phenotype association analysis were performed. Results: The C allele of rs2910164 in MIR146A was associated with higher values of IVCM parameters and minimum rim width (MRW) of the peripapillary region of optic nerve head measured in the retina, whereas the T allele of rs1188095 in MIR128A was associated with a significant impairment of them. Multiple regression analysis showed that MIR146A and MIR128A polymorphisms were significantly associated with corneal nerve fiber length (beta = 0.225 and - 0.204, respectively) and other IVCM parameters, independently from age, diabetes duration, HbA1c and systolic blood pressure percentile. Similar results were found for MRW (beta = 0.213 and - 0.286, respectively). Conclusions: These results provide new insight into the genetic predisposition to DN showing that two polymorphisms in MIR146A and MIR128A genes could significantly contribute to the development of early ocular preclinical signs of DN

Associations between higher plasma ferritin and hepcidin levels with liver stiffness in patients with type 2 diabetes: An exploratory study

Background: Currently, there is no information about the association between circulating levels of ferritin and hepcidin and liver fibrosis in patients with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). Methods: We enrolled 153 patients with T2DM with no known liver diseases, who consecutively attended our diabetes outpatient service and who underwent liver ultrasonography and liver stiffness measurement (LSM) by vibration-controlled transient elastography (Fibroscan® for the non-invasive assessment of liver fibrosis). Plasma ferritin and hepcidin concentrations were measured with an electrochemiluminescence immunoassay and mass spectrometry-based assay, respectively. Results: After stratification of patients by LSM tertiles [1st tertile median LSM: 3.6 (interquartile range: 3.3-4.0) kPa, 2nd tertile: 5.3 (4.9-5.9) kPa and 3rd tertile: 7.9 (6.7-9.4) kPa], we found that plasma ferritin and hepcidin concentrations increased across LSM tertiles [median ferritin: 68.7 (interquartile range: 25.1-147) vs. 85.8 (48.3-139) vs. 111 (59.3-203) μg/L, p = 0.021; median hepcidin: 2.5 (1.1-5.2) vs. 4.4 (2.5-7.3) vs. 4.1 (1.9-6.8) nmol/L, p = 0.032]. After adjustment for age, sex, diabetes duration, waist circumference, haemoglobin A1c, HOMA-insulin resistance score, triglycerides, haemoglobin, presence of hepatic steatosis on ultrasonography and patatin-like phospholipase domain-containing-3 (PNPLA3) rs738409 genetic variant, higher plasma ferritin levels were associated with greater LSM values (adjusted-odds ratio 2.10, 95% confidence interval 1.23-3.57, p = 0.005). Higher plasma hepcidin levels were also associated with greater LSM values (adjusted-odds ratio 1.90, 95% confidence interval 1.15-3.13, p = 0.013). Conclusions: Higher levels of plasma ferritin and hepcidin were associated with greater NAFLD-related liver fibrosis (assessed by LSM) in patients with T2DM, even after adjustment for established cardiometabolic risk factors, diabetes-related variables and other potential confounders

Calibration activities on the BepiColombo High-Resolution Channel (HRIC) of SIMBIO-SYS instrument

HRIC (High Resolution Imaging Channel) is the high resolution channel of the SIMBIO-SYS instrument on- board the ESA BepiColombo Mission. Calibration activities were performed at SelexES premises in spring- summer 2014 in order to check for Channel performances (radiometric performances, quality image and geometrical performances) and to obtain data necessary to setup a calibration pipeline necessary to process the raw images acquired by the channel when in operative scenario

Planning the HRIC (High Resolution Imaging Channel) observations of Mercury surface

The High Resolution Imaging Channel (HRIC) of SIMBIOSYS [1]onboard the BepiColombo mission to Mercury, is the visible imaging camera devoted to the detailed characterization of the Hermean surface. The potential huge amount of data that HRIC can produce must cope with the allocated (and shared) mission resources in terms of power, data volume,and pointing maneuvers. For this reason , well before the mission launch, it is extremely important the definition of an operative plan compatible with both the available resources and the scientific objectives accomplishment

Impact of CFTR Modulators on Beta-Cell Function in Children and Young Adults with Cystic Fibrosis

Background: To date, no consistent data are available on the possible impact of CFTR modulators on glucose metabolism. The aim of this study was to test the hypothesis that treatment with CFTR modulators is associated with an improvement in the key direct determinants of glucose regulation in children and young adults affected by Cystic Fibrosis (CF). Methods: In this study, 21 CF patients aged 10–25 underwent oral glucose tolerance test (OGTT) before and after 12–18 months of treatment with Lumacaftor/Ivacaftor or Elexacaftor-Ivacaftor-Tezacaftor. β-cell function (i.e., first and second phase of insulin secretion measured as derivative and proportional control, respectively) and insulin clearance were estimated by OGTT mathematical modelling. Insulin sensitivity was estimated by the Oral Glucose Sensitivity Index (OGIS). The dynamic interplay between β-cell function, insulin clearance and insulin sensitivity was analysed by vector plots of glucose-stimulated insulin bioavailability vs. insulin sensitivity. Results: No changes in glucose tolerance occurred after either treatment, whereas a significant improvement in pulmonary function and chronic bacterial infection was observed. Beta cell function and insulin clearance did not change in both treatment groups. Insulin sensitivity worsened in the Lumacaftor/Ivacaftor group. The analysis of vector plots confirmed that glucose regulation was stable in both groups. Conclusions: Treatment of CF patients with CFTR modulators does not significantly ameliorate glucose homeostasis and/or any of its direct determinants